Intramolecular direct arylation in an A,C-functionalized calix[4]arene.

نویسندگان

  • Olaf G Barton
  • B Neumann
  • H-G Stammler
  • Jochen Mattay
چکیده

A recently developed efficient method for intramolecular direct arylation is employed on a doubly functionalized calix[4]arene fixed in the cone conformation. The reaction takes place in high yield leading to meta substituted calix[4]arenes. The functionalities are located at two opposite aromatic rings and the two possible diastereomers are obtained in a 1:1 ratio. Full sets of data including crystal structures for both isomers are presented. The NMR data reveal that even at temperatures up to 120 degrees C both isomers are fixed in a flattened cone conformation with the substituted aromatic units pointing outwards.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 6 1  شماره 

صفحات  -

تاریخ انتشار 2008